| Charlie Cox | Matt Murdock |
| Deborah Ann Woll | Karen Page |
| Elden Henson | Foggy Nelson |
| Joanne Whalley | Sister Maggie |
| Jay Ali | Ray Nadeem |
| Wilson Bethel | Benjamin 'Dex' Poindexter |
| Vincent D'Onofrio | Wilson Fisk |
| Peter McRobbie | Father Lantom |
| Lesley Ann Warren | Esther Falb |
| Danny Johnson | Benjamin Donovan |
| Royce Johnson | Brett Mahoney |
| Stephen Rowe | Nicholas Lee |
| Kate Udall | SAC Tammy Hattley |
| Peter Halpin | Theo Nelson |
| Sunita Deshpande | Seema Nadeem |
| Noah Huq | Sami Nadeem |
| Matthew McCurdy | Agent Wellers |
| David Anthony Buglione | Agent Johnson |
| Don Castro | Agent Arinori |
| Adriana Santos | Young Nun |
| Carleton King | Officer Minelli |
| Ron Simons | NYPD Captain Strieber |
| Britt Sanborn | NYPD Cop |
| Matthew Streeter | NYPD ESU Leader |
| Candice Gordon | NYPD Crime Scene Tech
(as Candice Tiffany Gordon) |
| Michael DeBarge | NYPD Crime Scene Tech
(as Michael DeBarge) |
| Jamaal Burcher | FBI Agent
(uncredited) |
| John DiGiorgio | FBI Agent
(uncredited) |
| Frank Fernandez | Panicked Parishioner
(uncredited) |
| Bob Leszczak | TV Cameraman
(uncredited) |
| Ashley North | Panicked Parishioner
(uncredited) |
| Danny Schoch | Panicked Parishioner
(uncredited) |