| Charlie Cox | Matt Murdock |
| Deborah Ann Woll | Karen Page |
| Elden Henson | Foggy Nelson |
| Joanne Whalley | Sister Maggie |
| Jay Ali | Ray Nadeem |
| Wilson Bethel | Benjamin 'Dex' Poindexter |
| Vincent D'Onofrio | Wilson Fisk |
| Geoffrey Cantor | Mitchell Ellison |
| Kate Udall | SAC Tammy Hattley |
| Joe Jones | Felix Manning |
| Stephen Rowe | Nicholas Lee |
| Andrew Sensenig | OPR Agent Winn |
| Kimberli Flores | Agent Alvarez
(as Kimberli Alexis Flores) |
| Matt Deangelis | Jasper Evans
(as Matt DeAngelis) |
| Marcus Antturi | Elton Evans |
| Libby George | Old Lady Evans |
| David Anthony Buglione | Agent Johnson |
| Sam Slater | Agent O'Connor |
| Corey Pierno | Reporter #3 |
| Brandon Morris | NYPD Detective |
| Erika Myers | Female Security Guard |
| Holly Cinnamon | Julie Barnes
(voice) (uncredited) |
| Tristan Laurence | Reporter
(uncredited) |