| Jon Hamm | Don Draper |
| Elisabeth Moss | Peggy Olson |
| Vincent Kartheiser | Pete Campbell |
| January Jones | Betty Draper |
| Christina Hendricks | Joan Holloway |
| Bryan Batt | Salvatore Romano |
| Michael Gladis | Paul Kinsey |
| Aaron Staton | Ken Cosgrove |
| Rich Sommer | Harry Crane |
| Maggie Siff | Rachel Menken
(credit only) |
| Robert Morse | Bertram Cooper |
| John Slattery | Roger Sterling |
| Nathan Anderson | Ronnie Gittridge |
| Anne Dudek | Francine Hanson |
| Crista Flanagan | Lois Sadler |
| H. Richard Greene | Jim Hobart |
| Andy Umberger | Dr. Arnold Wayne |
| Dey Young | Adele Hobart |
| Stephanie Courtney | Marge |
| Maxwell Huckabee | Robert Draper |
| Julie McNiven | Hildy |
| Rick Scarry | Ross Beresford |
| Kiernan Shipka | Sally Draper |
| Dawn Marie Anderson | Receptionist
(uncredited) |
| Claire Bocking | Secretary
(uncredited) |
| Jakob Bokulich | Coke Husband
(uncredited) |
| Candice Cunningham | Secretary
(uncredited) |
| Eve Curtis | Secretary
(uncredited) |
| Emelle | Secretary
(uncredited) |
| Gloria A Feralio | Ethel
(uncredited) |
| Monica Ford | Secretary
(uncredited) |
| Jacqueline Kennedy | Self
(archive footage) (uncredited) |
| Dominika Pyk | Secretary
(uncredited) |
| Jade Ramsey | Auditioning Twin #1
(uncredited) |
| Nikita Ramsey | Auditioning Twin #2
(uncredited) |
| Jennifer Sims | Secretary
(uncredited) |
| Arne Starr | The Artist
(uncredited) |
| Brooke Stone | Louise
(uncredited) |