| Tom Ellis | Lucifer Morningstar |
| Lauren German | Chloe Decker |
| Kevin Alejandro | Dan Espinoza |
| Tricia Helfer | Charlotte |
| D.B. Woodside | Amenadiel
(as DB Woodside) |
| Lesley-Ann Brandt | Mazikeen |
| Aimee Garcia | Ella Lopez |
| Scarlett Estevez | Trixie Espinoza |
| Tom Welling | Marcus Pierce |
| Rachael Harris | Linda Martin |
| Eric Nenninger | Frederick Hoffman |
| Billy Malone | Vincent Walker |
| Victoria Gabrielle Platt | Dr. Valerie Haynes
(as Victoria Platt) |
| Aloma Wright | Party Bus Driver |
| Erik Armando Alvarez | Bouncer
(as Erik Alvarez) |
| Lauren Baldwin | Meg Boyd |
| Kevin Covais | Frazzled P.A. |
| Christian Gehring | Logan |
| Roslyn Gentle | Snooty Owner
(as Ros Gentle) |
| Sean Harris | Brock |
| David Labrava | Mike |
| Sari Sanchez | Tabitha |
| Jon Buckhouse | Club Patron
(uncredited) |
| Rusnico Canonigo Jr. | EMT Tech
(uncredited) |
| Bruce M. Stockert | Man at Dog Show
(uncredited) |
| Christina Veronica | Poker Player
(uncredited) |