| Tom Ellis | Lucifer Morningstar |
| Lauren German | Chloe Decker |
| Kevin Alejandro | Dan Espinoza |
| Tricia Helfer | Charlotte |
| D.B. Woodside | Amenadiel
(as DB Woodside) |
| Lesley-Ann Brandt | Mazikeen |
| Aimee Garcia | Ella Lopez |
| Scarlett Estevez | Trixie Espinoza
(credit only) |
| Tom Welling | Marcus Pierce |
| Rachael Harris | Linda Martin |
| Kate Beahan | Justine Doble |
| Donny Boaz | 'Dangerous Doug' Libby |
| Sonya Balmores | Wild Child |
| Justin Johnson Cortez | Manny 'The Moondog' Taylor
(as Justin Johnson-Cortez) |
| Rick Kelly | Tyler Utah |
| Jess Lundgren | Orca
(as Jess Kaala Lundgren) |
| David Paladino | Johnny Utah |
| David Grant Wright | Dr. Kaminsky |
| Megan Harmon | Hot Girl at Pool Party
(uncredited) |