| Tom Ellis | Lucifer Morningstar |
| Lauren German | Chloe Decker |
| Kevin Alejandro | Dan Espinoza |
| D.B. Woodside | Amenadiel
(as DB Woodside) (credit only) |
| Lesley-Ann Brandt | Mazikeen |
| Tricia Helfer | Charlotte
(credit only) |
| Aimee Garcia | Ella Lopez |
| Scarlett Estevez | Trixie Espinoza
(credit only) |
| Rachael Harris | Linda Martin |
| Patrick Fabian | Reese Getty |
| John Billingsley | Alvin Kapitski |
| Shelley Robertson | Editor |
| Bree Condon | Veronica |
| Fiona Vroom | Nurse |
| Parker Brando | Dude with Neck Tattoos |
| Bianca Caroca | Frisky Woman #2 |
| Jessica Garcie | Young Woman Poisoned
(as Jessica Garcia) |
| Doreen Gordon | Waitress |
| Keilani Elizabeth Rose | Frisky Woman #1
(as Keilani Jung) |
| Victoria Katongo | Cute Uni
(as Tori Katongo) |
| Henry Mah | Custodian |
| Christopher Pearce | Barry |
| Edwin Perez | Chad |
| Trent Redekop | Beefy Uni |
| Alla Rouba | Young Woman's Friend |
| Alan Silverman | Grizzled Detective |
| Jon Buckhouse | Club Patron
(uncredited) |
| Vincent Lionetti | Neighbor
(uncredited) |