| Naveen Andrews | Sayid Jarrah |
| Henry Ian Cusick | Desmond Hume
(credit only) |
| Jeremy Davies | Dr. Daniel Faraday
(credit only) |
| Michael Emerson | Ben Linus |
| Matthew Fox | Dr. Jack Shephard |
| Jorge Garcia | Hugo 'Hurley' Reyes |
| Josh Holloway | James 'Sawyer' Ford
(credit only) |
| Daniel Dae Kim | Jin-Soo Kwon
(credit only) |
| Yunjin Kim | Sun-Hwa Kwon
(credit only) |
| Ken Leung | Miles Straume
(credit only) |
| Evangeline Lilly | Kate Austen |
| Elizabeth Mitchell | Dr. Juliet Burke
(credit only) |
| Terry O'Quinn | John Locke |
| Alan Dale | Charles Widmore |
| Malcolm David Kelley | Walt Lloyd |
| Lance Reddick | Matthew Abaddon |
| Zuleikha Robinson | Ilana Verdansky |
| Saïd Taghmaoui | Caesar |
| William Blanchette | Aaron
(credit only) |
| John Jamal Bradley | Kid
(as J.J. Bradley) |
| Ammar Daraiseh | Hajer |
| Concepcion Alicino-Saucedo | Sister Consuela
(as Concepcion Saucedo) |
| Stephen Scibetta | Construction Foreman |
| Grisel Reyes | Susie
(as Grisel Toledo) |
| Dennis Falt | Ajira Flight 316 Survivor
(uncredited) |
| John Terry | Dr. Christian Shephard
(archive footage) (uncredited) |