| Naveen Andrews | Sayid Jarrah |
| Henry Ian Cusick | Desmond Hume |
| Emilie de Ravin | Claire Littleton |
| Michael Emerson | Ben Linus
(credit only) |
| Matthew Fox | Dr. Jack Shephard
(credit only) |
| Jorge Garcia | Hugo 'Hurley' Reyes |
| Josh Holloway | James 'Sawyer' Ford
(credit only) |
| Daniel Dae Kim | Jin-Soo Kwon
(credit only) |
| Yunjin Kim | Sun-Hwa Kwon |
| Evangeline Lilly | Kate Austen
(credit only) |
| Elizabeth Mitchell | Dr. Juliet Burke
(credit only) |
| Dominic Monaghan | Charlie Pace |
| Terry O'Quinn | John Locke |
| Kiele Sanchez | Nikki Fernandez
(credit only) |
| Rodrigo Santoro | Paulo
(credit only) |
| Sonya Walger | Penelope 'Penny' Widmore |
| Alan Dale | Charles Widmore |
| Shishir Kurup | Donovan |
| Fionnula Flanagan | Eloise 'Ellie' Hawking |
| Jeremy Colvin | Delivery Man |
| David Cordell | Jimmy Lennon |
| Katie Doyle | Receptionist |
| Michael Titterton | Bartender |
| Stephen Quinn | Photographer |
| Larry Wegger | Hospital Patient
(uncredited) |