| Matthew Fox | Dr. Jack Shephard |
| Evangeline Lilly | Kate Austen |
| Terry O'Quinn | John Locke |
| Naveen Andrews | Sayid Jarrah |
| Jorge Garcia | Hugo 'Hurley' Reyes |
| Emilie de Ravin | Claire Littleton |
| Josh Holloway | James 'Sawyer' Ford |
| Daniel Dae Kim | Jin-Soo Kwon |
| Yunjin Kim | Sun-Hwa Kwon |
| Dominic Monaghan | Charlie Pace |
| Maggie Grace | Shannon Rutherford |
| Ian Somerhalder | Boone Carlyle |
| Harold Perrineau | Michael Dawson |
| Malcolm David Kelley | Walt Lloyd |
| L. Scott Caldwell | Rose Nadler |
| Fredric Lehne | Marshal Edward Mars
(as Fredric Lane) |
| Kimberley Joseph | Flight Attendant #1 |
| Jonathan Dixon | Flight Attendant #2
(as Jon Dixon) |
| Michelle Arthur | Flight Attendant #3 |
| Dale Radomski | Tourniquet Man |
| Geoff Heise | Man |
| Barbara Vidinha-Tyler | Woman
(as Barbara Vidinha) |
| Benjamin P. Binswanger | Plane Passenger
(uncredited) |
| Christian Bowman | Steve Jenkins
(uncredited) |
| Faith Fay | Survivior
(uncredited) |
| Greg Grunberg | Seth Norris
(uncredited) |
| Dane Justman | Survivor
(uncredited) |
| Madison | Vincent the Dog
(uncredited) |
| Frank Torres | Gary Troup
(uncredited) |
| Dustin Watchman | Scott Jackson
(uncredited) |