| George Dzundza | Sergeant Max Greevey |
| Chris Noth | Detective Mike Logan |
| Dann Florek | Captain Donald Cragen |
| Michael Moriarty | E.A.D.A. Ben Stone |
| Richard Brooks | A.D.A. Paul Robinette |
| Steven Hill | D.A. Adam Schiff |
| Paul Sparer | Dr. Edward Auster |
| John Spencer | Howard Morton |
| Ron Rifkin | Defense Attorney Phillip Nevins |
| Erick Avari | Dr. 'Ekballa' Raza |
| Alvin Epstein | Dr. Chester |
| Maryann Urbano | Dr. Jean Mills |
| Bruce McCarty | Dr. Stephen Simonson |
| Ed Setrakian | Hoffman |
| W.T. Martin | Dr. Lignell |
| Daniel Benzali | Medical Examiner |
| Frederica Meister | Mrs. Melanie Stivic |
| Annie Corley | Stewart |
| Rocky Carroll | Dr. Davids |
| William Roerick | Dr. Robert Abraham |
| Russell Horton | Markham Markowitz |
| Tom Kubiak | Dr. Rasmussen |
| Harry S. Murphy | Don |
| Maeve McGuire | Dr. Walters |
| Stephanie J. Gordon | Nurse |
| Kate Wilkinson | Gray-Haired Lady |
| Shona Tucker | Records Clerk |
| Nick Damici | Officer Dubuque |
| Leslie Goldman | Trial Judge Benjamin Harcourt |
| Chaz McCormack | McInerny |
| Lee Tergesen | Clemens |
| Joan Kaye | Nurse |
| Sean Whitesell | Intern |
| Marshall Dancing Elk Lucas | |
| Lewis Musser | Crime Scene Photographer |
| Bruklin Harris | Hospital Clerk |
| Erika Jayne | Suzanne Morton |
| Avis McCarther | Secretary |
| Derrick Simmons | Stabber |
| Steven Zirnkilton | Narrator - Opening Title Sequence |