| Viola Davis | Annalise Keating |
| Billy Brown | Nate Lahey |
| Alfred Enoch | Wes Gibbins |
| Jack Falahee | Connor Walsh |
| Aja Naomi King | Michaela Pratt |
| Matt McGorry | Asher Millstone |
| Conrad Ricamora | Oliver Hampton |
| Karla Souza | Laurel Castillo |
| Charlie Weber | Frank Delfino |
| Liza Weil | Bonnie Winterbottom |
| Luna Lauren Velez | Soraya Hargrove
(as Luna Vélez) |
| Benito Martinez | Todd Denver |
| Milauna Jackson | Renee Atwood
(as Milauna Jemai Jackson) |
| Jacqueline Hahn | Barbara Jacobs |
| Gloria Garayua | Brianna Davis |
| Susan Chuang | Ingrid Peters |
| David Raibon | Howie |
| Racheal Seymour | Officer Henderson
(uncredited) |