| Viola Davis | Annalise Keating |
| Billy Brown | Nate Lahey |
| Alfred Enoch | Wes Gibbins |
| Jack Falahee | Connor Walsh |
| Aja Naomi King | Michaela Pratt |
| Matt McGorry | Asher Millstone |
| Conrad Ricamora | Oliver Hampton |
| Karla Souza | Laurel Castillo |
| Charlie Weber | Frank Delfino |
| Liza Weil | Bonnie Winterbottom |
| Benito Martinez | Todd Denver |
| L. Scott Caldwell | Jasmine Bromelle |
| Roger Robinson | Mac Harkness |
| Milauna Jackson | Renee Atwood
(as Milauna Jemai Jackson) |
| Brian Tyree Henry | Frank's Public Defender |
| Yolonda Ross | Claudia Gelvin |
| Corbin Reid | Meggy Travers |
| Jacqueline Hahn | Barbara Jacobs |
| Gloria Garayua | Brianna Davis |
| Behzad Dabu | Simon Drake |
| Cicely Tyson | Ophelia Harkness |
| Racheal Seymour | Officer Henderson |
| Ellen Haun | Ms. Chapin |
| Tiffany Jeneen | Morgue Clerk |
| J. Anthony Pena | Prison Guard |
| Charmel Catrell | Sheriff's Deputy |
| John Thaddeus | Cabbie |
| Trisha Rae Stahl | New Prisoner |
| Charles Greer IV | Luis
(as Charles W. Greer IV) |
| Shamori Washington | Tyrone |
| Alex Daniels | Jay Walker
(uncredited) |
| Nohely Quiroz | Law Student Lowell
(uncredited) |