| Viola Davis | Annalise Keating |
| Billy Brown | Nate Lahey |
| Alfred Enoch | Wes Gibbins |
| Jack Falahee | Connor Walsh |
| Aja Naomi King | Michaela Pratt |
| Matt McGorry | Asher Millstone |
| Conrad Ricamora | Oliver Hampton |
| Karla Souza | Laurel Castillo |
| Charlie Weber | Frank Delfino |
| Liza Weil | Bonnie Winterbottom |
| Luna Lauren Velez | Soraya Hargrove
(as Luna Vélez) |
| Anne Gee Byrd | Edith Duvall |
| Corbin Reid | Meggy Travers |
| Behzad Dabu | Simon Drake |
| Jason Brooks | Nelson Duvall |
| Leif Gantvoort | Jared Duvall |
| Annie Tedesco | Karen Duvall |
| Suleka Mathew | Dana Benton |
| Dameon Clarke | John Mumford
(as Dameon J. Clarke) |
| Gloria Garayua | Brianna Davis |
| Albie Selznick | A.D.A. Holland |
| Mark L. Taylor | Vince Levin |
| Matthew Risch | Thomas |
| Toni Torres | Detective Phillipe |
| Eme Ikwuakor | Hank |
| Adrienne Bankert | Reporter |
| Dionne Audain | AA Woman |
| Margaret Newborn | AA Member
(uncredited) |
| Nohely Quiroz | Law Student Lowell
(uncredited) |