| Viola Davis | Annalise Keating |
| Billy Brown | Nate Lahey |
| Alfred Enoch | Wes Gibbins |
| Jack Falahee | Connor Walsh |
| Aja Naomi King | Michaela Pratt |
| Matt McGorry | Asher Millstone |
| Conrad Ricamora | Oliver Hampton |
| Karla Souza | Laurel Castillo |
| Charlie Weber | Frank Delfino |
| Liza Weil | Bonnie Winterbottom |
| Esai Morales | Jorge Castillo |
| Luna Lauren Velez | Soraya Hargrove
(as Luna Vélez) |
| Austin Basis | Toby Solomon |
| Milauna Jackson | Renee Atwood
(as Milauna Jemai Jackson) |
| Corbin Reid | Meggy Travers |
| Kimiko Gelman | Ursela Mamoon |
| Dameon Clarke | John Mumford
(as Dameon J. Clarke) |
| John DeLuca | Matt |
| Behzad Dabu | Simon Drake |
| Carlye Tamaren | Janie Sherwin |
| Peggy Dunne | Sharon Sherwin |
| Tony Abatemarco | Judge Rodger Charters |
| Kalpana Pot | Ms. Gunderson |
| Gail Borges | Officer Bryant |
| Chuck Saculla | Officer |
| Mark Berry | Fire Chief Gaines |
| Amber Friendly | Tech Specialist |
| Peggy Blow | Croupier |
| Harrison White | Pawnshop Clerk |
| Kristopher Boutin | Lawyer
(uncredited) |
| Kadrolsha Ona Carole | Courtroom Spectator
(uncredited) |
| Celeste Cook | Rainey
(uncredited) |
| Jackie Ganz | Virginia Michaelson
(uncredited) |
| John Paul Jones II | Law Student
(uncredited) |
| Lauren Lynn King | Diana
(uncredited) |
| Waymond Lee | Courtroom Spectator
(uncredited) |
| Nohely Quiroz | Law Student Lowell
(uncredited) |