| Viola Davis | Annalise Keating |
| Billy Brown | Nate Lahey |
| Alfred Enoch | Wes Gibbins |
| Jack Falahee | Connor Walsh |
| Aja Naomi King | Michaela Pratt |
| Matt McGorry | Asher Millstone |
| Conrad Ricamora | Oliver Hampton |
| Karla Souza | Laurel Castillo |
| Charlie Weber | Frank Delfino |
| Liza Weil | Bonnie Winterbottom |
| Amy Madigan | Irene Crowley |
| Luna Lauren Velez | Soraya Hargrove
(as Luna Vélez) |
| Lily Knight | Amber Crowley |
| Corbin Reid | Meggy Travers |
| Kim Robillard | Commissioner Graves |
| Josh Clark | Commissioner Monaghan |
| Dameon Clarke | John Mumford
(as Dameon J. Clarke) |
| Gloria Garayua | Brianna Davis |
| Behzad Dabu | Simon Drake |
| Chet Grissom | HR Lawyer |
| Michael Peter Bolus | Butch Man |
| Mark Berry | Fire Chief Gaines |
| Dani Haberman | Law Student
(uncredited) |
| John Paul Jones II | Law Student
(uncredited) |
| Nohely Quiroz | Law Student Lowell
(uncredited) |