| Viola Davis | Annalise Keating |
| Billy Brown | Nate Lahey |
| Alfred Enoch | Wes Gibbins |
| Jack Falahee | Connor Walsh |
| Aja Naomi King | Michaela Pratt |
| Matt McGorry | Asher Millstone |
| Karla Souza | Laurel Castillo |
| Charlie Weber | Frank Delfino |
| Liza Weil | Bonnie Winterbottom |
| Sarah Burns | Emily Sinclair |
| Conrad Ricamora | Oliver Hampton |
| Barbara Eve Harris | Fiona Pruitt |
| Bonita Friedericy | Sandra Guthrie |
| Wayne Wilderson | Jeremy Eastham |
| Matt Cohen | Levi Wescott |
| Amy Okuda | Catherine Hapstall |
| Kendrick Sampson | Caleb Hapstall |
| Famke Janssen | Eve Rothlo |
| Thomas W. Ashworth | Mr. Fisher |
| Roger Rignack | Detective Marshall Norwood |
| William Charlton | Judge Lester Tipton |
| Sope Aluko | Detective Shelby Diaz |
| Beth Payne | Busty Woman |
| Maurice Webster | Tipstaff |
| Vivan Dugré | News Reporter
(uncredited) |
| Toni French | Pedestrian /
Dive Bar Patron
(uncredited) |
| Punnavith Koy | Reporter
(uncredited) |
| Jeremy J. Sykes | Plaintiff in Precinct
(uncredited) |