| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Diane Lane | Annette Shepherd |
| Campbell Scott | Mark Usher |
| Boris McGiver | Tom Hammerschmidt |
| Derek Cecil | Seth Grayson |
| Greg Kinnear | Bill Shepherd |
| Cody Fern | Duncan Shepherd |
| Constance Zimmer | Janine Skorsky |
| Chip Zien | Dr. Charles Rosen |
| Brian Keane | Ray Meyers |
| Joy Lynn Jacobs | U.S. Attorney |
| Kristen Sieh | Kelsey Stewart |
| Susan Pourfar | Nora Cafferty |
| Jeremy Holm | Nathan Green |
| Lee R. Sellars | Roger Olmstead
(as Lee Sellars) |
| Ron Canada | Vincent Abruzzo |
| Robert Newman | EPA Administrator |
| Aaron Serotsky | Russell |
| Nat DeWolf | Plant Representative |
| Tom O'Keefe | EPA Regional Administrator |
| Jim Acosta | Jim Acosta |
| Theresa McCarthy | Dr. Larson |
| Tim Pabon | Reporter |
| Lora Lee Gayer | Reporter |
| Stephanie Umoh | Reporter |
| Julie Mun | Reporter |
| Kristen Adele | Usher's Aide |
| Nini Le Huynh | Lynn Phang |
| Ann Charles Sutton | Young Claire |
| Kacy Gabbert | Bellport Resident |
| Amy Lynn Stewart | Claire's Mother |
| Robert T. Bogue | Claire's Father
(as Robert Bogue) |
| Gregory Divers | White House Press Corps |
| Lucky Harmon | Videographer |
| Emet Mihajlo | Pvt. Ortiz |
| Antoinette Montgomery | White House Press Corps |
| Whitney Richardson | Intern |
| Dan Verkman | White House Press Corp |
| Charlita Woodruff | White House Press Corp |
| Matthew Bernard | Press
(uncredited) |
| Jen Ayer Drake | Victim
(uncredited) |
| Dave Ferrier | Videographer
(uncredited) |
| Ryan Hinson | Ohio Victim
(uncredited) |
| Mack Jones | White House Press
(uncredited) |
| Gina Jun | Staff
(uncredited) |
| Stephanie Parker | Secret Service
(uncredited) |
| Molly Ross | Aim High Girl
(uncredited) |
| Edward Stachyra | Fundraiser Attendee
(uncredited) |
| Valeria Volynkina | Upscale Party Guest
(uncredited) |
| Dennis Wildberger | Guest at Fundraiser
(uncredited) |
| Tim R. Worley | Foreign Press Corps
(uncredited) |
| Mars Xexelia | Shepherd Foundation Staffer
(uncredited) |