| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Mahershala Ali | Remy Danton |
| Neve Campbell | Leann Harvey |
| Boris McGiver | Tom Hammerschmidt |
| Paul Sparks | Thomas Yates |
| Joel Kinnaman | Will Conway |
| Jayne Atkinson | Catherine Durant |
| Reg E. Cathey | Freddy |
| Colm Feore | General Brockhart |
| Damian Young | Aidan Macallan |
| Andrew Polk | Harry Marshall |
| Kathleen Chalfant | Margaret Tilden |
| Wendy Moniz | Laura Moretti |
| John Rue | CIA Director |
| Julian Gamble | Chairman of the Joint Chiefs |
| James Saito | Dr. Krebs |
| Pippa Pearthree | Helen |
| Amy Hohn | Debbie Simms |
| Robert C. Treveiler | Karl Simms
(as Rob Treveiler) |
| Joy Kigin | Stamper's Secretary |
| Nini Le Huynh | Claire's Assistant
(as Nini Huynh) |
| Felix Stevenson | WH Steward |
| Lionel | Radio Host |
| Shannon Mulaire | News Anchor |
| John Trout | News Anchor |
| Tricia Sawyer | Cosmetologist |
| Draaco Aventura | WH Press Corps |
| Cody Bennett | Bar Patron |
| Rick Kelvin Branch | Hotel Guest |
| Loretta Burnette | Reporter |
| Stephanie Cookie Carson | Reporter |
| Finn Douglas | Charlie Conway |
| Andre Faulcon | Conway Security |
| Michael Harding | Governor Parsons |
| Misti Morningstar | Rally Photographer |
| Tatyana N. Pokrovskaya | Patron |
| John Wells | Farmer |
| Joshua Barnes | Police Officer
(uncredited) |
| Todd Bobenrieth | Delegate
(uncredited) |
| Toshi Calderón | Jazz Club Hipster
(uncredited) |
| Lauren Cox | Claire's Secret Service
(uncredited) |
| Justin Doescher | Frank Underwood Security
(uncredited) |
| Lamont Easter | Underwood Secret Service
(uncredited) |
| Lindsay Dyan Epp | White House Press
(uncredited) |
| Mark Falvo | News Photgrapher
(uncredited) |
| Jessica J. Immanuel | Supporter
(uncredited) |
| Antoinette Montgomery | White House Press Corps
(uncredited) |
| Bill Ward | DNC Attendee /
Senate Staffer /
Senator /
Press
(uncredited) |
| Kimia' Workman | Traveler
(uncredited) |