| Kevin Spacey | Francis Underwood |
| Robin Wright | Claire Underwood |
| Michael Kelly | Doug Stamper |
| Mahershala Ali | Remy Danton |
| Molly Parker | Jackie Sharp |
| Elizabeth Marvel | Heather Dunbar |
| Derek Cecil | Seth Grayson |
| Jimmi Simpson | Gavin Orsay |
| Nathan Darrow | Edward Meechum |
| Paul Sparks | Thomas Yates |
| Reg E. Cathey | Freddy |
| Reed Birney | VP Donald Blythe |
| Kelly AuCoin | Gary Stamper |
| Shawn Doyle | Dr. Alan Cooke |
| Rachel Brosnahan | Rachel Posner |
| David Eichenbaum | Abbott Vaughn |
| Michelle Kosinski | Michelle Kosinski |
| John King | John King |
| George Stephanopoulos | George Stephanopoulos |
| Matthew Dowd | Matthew Dowd |
| Donna Brazile | Donna Brazile |
| Helen E. McNutt | Agnes
(as Helen McNutt) |
| Kris Arnold | Field Office Director |
| Amy Garber | Nurse |
| Judah Sandridge | Little Kid |
| Andrea Leigh | WH Secretary |
| Makeda Vaughn | Make-Up Artist |
| John Paul Andrews | Campaign Staffer |
| Chrislene Bright | White House Press Corp. |
| Gregory Divers | Debate Press |
| Michelle Xander Gruver | Campaign Volunteer |
| Nini Le Huynh | Claire's Assistant
(as Nini Huynh) |
| Dawn Kopecki | Dawn Kopecki |
| James Krehely | Debate Background |
| Jaclyn McHugh | Dunbar Supporter |
| Laura Beth Melchiorre | Debate Attendee |
| John Peddie | Debate audience member |
| Garrett Pietrocola | Garrett Pietrocola |
| Carla Saylor | Campaign Volunteer |
| Lori Titus | Debate Attendee |
| Marla Aaron Wapner | WH Press Corp |
| Eric Bass | Classy Man
(uncredited) |
| Shira Bethea | Campaign Volunteer
(uncredited) |
| Alice Bozga | Campaign Staffer
(uncredited) |
| Maria Diavolitsis | Political Event Rallier
(uncredited) |
| Justin Doescher | Frank Underwood Security
(uncredited) |
| Dawn A. Douglas | Claire Secret Service
(uncredited) |
| Lamont Easter | Underwood Secret Service
(uncredited) |
| Mark Falvo | Iowa Resident
(uncredited) |
| Dave Ferrier | Videographer
(uncredited) |
| Joseph Giambrone | Doctor
(uncredited) |
| Marc Goodman | Debate Attendee
(uncredited) |
| John Jarvis | Sharpe Aide
(uncredited) |
| Jennifer Lavi | Presidential Debate Attendee
(uncredited) |
| Mark Salas | Debate Attendee
(uncredited) |
| John Wells | Reporter
(uncredited) |