| Kevin Costner | 'Devil' Anse Hatfield |
| Bill Paxton | Randall McCoy |
| Matt Barr | Johnse Hatfield |
| Tom Berenger | Jim Vance |
| Powers Boothe | Judge Valentine 'Wall' Hatfield |
| Andrew Howard | 'Bad' Frank Phillips |
| Jena Malone | Nancy McCoy |
| Sarah Parish | Levicy Hatfield |
| Lindsay Pulsipher | Roseanna McCoy |
| Ronan Vibert | Perry Cline |
| Joe Absolom | Selkirk McCoy |
| Noel Fisher | Ellison 'Cotton Top' Mounts |
| Boyd Holbrook | William 'Cap' Hatfield |
| Tom McKay | Jim McCoy |
| Sam Reid | Tolbert McCoy |
| Jilon VanOver | Ransom Bray |
| Mare Winningham | Sally McCoy |
| Damian O'Hare | Ellison Hatfield |
| Greg Patmore | Good Lias Hatfield |
| Andy Gathergood | Skunkhair Tom Wallace |
| Christopher Hatherall | French Ellis |
| Noah Taylor | Lark Varney |
| John Bell | Billy Dempsy |
| Max Deacon | Calvin McCoy |
| Ben Cartwright | Parris McCoy |
| Jack Laskey | Squirrel-Huntin' Sam McCoy |
| Jonathan Fredrick | Jefferson McCoy |
| Michael Jibson | Phamer McCoy |
| Chad Hugghins | Harmon McCoy |
| Tyler Jackson | Bud McCoy |
| Katie Griffiths | Alifair McCoy |
| Nick Dunning | Preacher Dyke Garrett |
| Alixandra von Renner | Kate Schoonover |
| Michael Woods | Cat Miller |
| James Carroll Jordan | Sheriff Maynard |
| Rob Moran | John B. Floyd |
| Joy McBrinn | Aunt Betty Blankenship |
| Jon Bloch | T. C. Crawford |
| Adam Jones | Bartender Wiggins |
| Michael Mears | Mr. Goodpasture |
| Rio Fanning | Farmer Volunteer |
| Levi Bowling | David Hatfield |
| Rebecca Calder | Martha McCoy |
| Park Chisolm | Urban Father |
| Darrell Fetty | Doc Rutherford |
| Michael Greco | Bill Staton |
| Stacha Hicks | Urban Mother |
| Lloyd Hutchinson | Floyd Hatfield |
| David Kennedy | Bob Levinger |
| Ian Mallitz | Jail Cell Drunk |
| Stuart Martin | Wounded Rebel Soldier |
| Bill Millsap | Rebel Prisoner |