| Blake Lively | Serena van der Woodsen |
| Leighton Meester | Blair Waldorf |
| Penn Badgley | Dan Humphrey |
| Chace Crawford | Nate Archibald |
| Taylor Momsen | Jenny Humphrey |
| Ed Westwick | Chuck Bass |
| Jessica Szohr | Vanessa Abrams |
| Kelly Rutherford | Lily van der Woodsen |
| Matthew Settle | Rufus Humphrey |
| Mädchen Amick | Duchess Catherine Beaton |
| Margaret Colin | Eleanor Waldorf |
| Yin Chang | Nelly Yuki |
| Patrick Heusinger | Lord Marcus Beaton |
| Michelle Hurd | Laurel |
| Amanda Setton | Penelope Shafai |
| Purva Bedi | Clare |
| Alexandra Carl | Laurel's Assistant |
| Gonzalo Escudero | VDW-Bass Butler |
| Amy Evinger | Atelier Model |
| Annalaina Marks | Chuck's Fling-Girl |
| Ellie Pettit | 12-Year-Old Nosey Girl #1 |
| Lydia Jordan | 12-Year-Old Nosey Girl #2 |
| Michaela Annette | 12-Year-Old Nosey Girl #3 |
| Kristen Bell | Gossip Girl |
| Joelle ten Damme | Stephanie |
| Mary DeBellis | Girl |
| Sara DeRosa | Text-Messaging Girl |
| Stephen Sapienza | Student |
| Mark Vincent | Chauffeur |