| Anthony Edwards | Mark Greene |
| Noah Wyle | John Carter |
| Laura Innes | Kerry Weaver |
| Alex Kingston | Elizabeth Corday |
| Paul McCrane | Robert Romano |
| Goran Visnjic | Luka Kovac |
| Maura Tierney | Abby Lockhart |
| Michael Michele | Cleo Finch |
| Erik Palladino | Dave Malucci |
| Ming-Na Wen | Jing-Mei Chen |
| Eriq La Salle | Peter Benton |
| Brent Jennings | Nat |
| Amy Aquino | Dr. Janet Coburn |
| Troy Evans | Frank Martin |
| Yvette Freeman | Nurse Haleh Adams |
| Mark Valley | Richard Lockhart |
| Deezer D | Nurse Malik McGrath |
| Lily Mariye | Nurse Lily Jarvik |
| Gerry Black | Mr. Fletcher |
| John Doe | Carter's Doctor |
| James T. Callahan | Mr. Bristol |
| Barry Gordon | Baxter |
| Jonathan Mangum | Med Student Ryan Bradford |
| Wentworth Miller | Mike Palmieri |
| Paula Newsome | Rehab Receptionist Margaret |
| Kay Lenz | Karen Palmieri |
| Lyn Alicia Henderson | Pamela Olbes |
| Dino Anello | Picketer |
| Purva Bedi | Med Student Priya Shilandra |
| Michelle C. Bonilla | Christine Harms |
| David Coggeshall | Teammate |
| Todd Duffey | Mitch |
| Jonathan T. Floyd | Student |
| Steve Howey | Quarterback Elizey |
| Jeremy Kent Jackson | Jock |
| Larissa LaRenne | Cheerleader |
| RonReaco Lee | Davis |
| Brian Lester | Brian Dumar |
| Sean McGowan | Food Court Guy |
| Bob Minor | Buck |
| J. Anthony Pena | Tackle |
| Hillary Straney | Flight Attendant |
| Tod Thawley | Smith |
| Emily Wagner | Doris Pickman |
| Dean Wein | Security Sergeant |
| Erin Carufel | Tiffany Stockton |
| Anthony DiCocco | Football Player |
| Lord KraVen | (uncredited) |