| Anthony Edwards | Mark Greene |
| George Clooney | Doug Ross |
| Noah Wyle | John Carter |
| Julianna Margulies | Carol Hathaway |
| Gloria Reuben | Jeanie Boulet |
| Laura Innes | Kerry Weaver |
| Alex Kingston | Elizabeth Corday |
| Kellie Martin | Lucy Knight |
| Eriq La Salle | Peter Benton |
| Abraham Benrubi | Jerry Markovic |
| Ellen Crawford | Nurse Lydia Wright |
| Paul Freeman | Dr. Charles Corday |
| Vince Vieluf | Bernard Gamely |
| Freda Foh Shen | Audiologist |
| Alan Blumenfeld | Rob Savage |
| Ted Rooney | Neonatologist Dr. Tabash |
| David Brisbin | Dr. Alexander Babcock |
| Debra Engle | Harriet Goodwyn |
| Rachel Robinson | Ms. Brown |
| Bernard White | Addict seeking Rapid Detox |
| Rita Zohar | Patient's Wife |
| Paul McCrane | Robert Romano |
| Yvonne Zima | Rachel Greene |
| Penny Johnson Jerald | Nurse Practitioner Lynette Evans |
| John Aylward | Dr. Donald Anspaugh |
| Conni Marie Brazelton | Nurse Connie Oligario |
| Gedde Watanabe | Nurse Yosh Takata |
| Emily Wagner | Doris Pickman |
| Montae Russell | Dwight Zadro |
| Lyn Alicia Henderson | Pamela Olbes |
| J.P. Hubbell | EMT Lars Audia |
| Suzanne Carney | OR Nurse Janet |
| Matt DeCaro | Soccer Dad |
| Tressa DiFiglia | Hannah |
| Kareem J. Grimes | B.G. |
| Cory Hardrict | Lil 'Toine |
| Glenn Walker Harris Jr. | Ruben |
| Taraji P. Henson | Elan |
| Reggie Lee | Christian |
| Ralph Monaco | Mr. Specchierla |
| Michael Moynihan | Forward |
| Jonathan Palmer | Dr. Blevins |
| Natasha Pearce | Moselle |
| Naomi Serotoff | Grace |
| Tiger Mendez | Police Officer |
| Konstantine Simakis | Young Construction Worker |