| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti
(credit only) |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Frank Vincent | Phil Leotardo |
| Ray Abruzzo | Carmine Lupertazzi Jr. |
| Dan Grimaldi | Patsy Parisi |
| Arthur J. Nascarella | Carlo Gervasi
(as Arthur Nascarella) |
| Peter Bogdanovich | Dr. Elliot Kupferberg |
| Matt Servitto | Agent Dwight Harris |
| Michael Kelly | Agent Ron Goddard |
| Cara Buono | Kelli Moltisanti |
| Greg Antonacci | Butch DeConcini
(as Gregory Antonacci) |
| Michael Countryman | Dr. Richard Vogel |
| Armen Garo | Salvatore 'Coco' Cogliano |
| John 'Cha Cha' Ciarcia | Albie Cianflone |
| Frank John Hughes | Walden Belfiore |
| John Cenatiempo | Anthony Maffei |
| Daniel Sauli | Patrick Parisi |
| Joey Perillo | John Stefano |
| Felix Solis | Edgar Ramirez |
| Dominic Chianese Jr. | Dominic |
| Lindsay Campbell | Professor Kline |
| Taleb Adlah | Ahmed |
| Donnie Keshawarz | Muhammed |
| Joey Scala | Teenager |
| Ed Kershen | Surveyor |
| Edward Furs | Driver |
| Chiko Mendez | Mental Patient
(uncredited) |
| Alyxx Morgen | Attending Nurse for AJ
(uncredited) |
| Ramy Shedid | Muslim
(uncredited) |