| James Gandolfini | Tony Soprano |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Aida Turturro | Janice Soprano Baccalieri |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Vincent Curatola | Johnny 'Sack' Sacramoni |
| Frank Vincent | Phil Leotardo |
| Joseph R. Gannascoli | Vito Spatafore |
| Dan Grimaldi | Patsy Parisi |
| Jerry Adler | Hesh Rabkin |
| Ron Leibman | Dr. Lior Plepler |
| Chris Diamantopoulos | Jason Barone |
| Anthony 'Treach' Criss | Marvin
(as Treach) |
| Lord Jamar | Da Lux |
| Rob Devaney | Bob Brewster |
| Craig muMs Grant | Mop
(as Mums) |
| Frances Ensemplare | Nucci
(as Frances Esemplare) |
| Michael DeNigris | Charles Cinelli
(as Michael De Nigris) |
| Angela Pietropinto | Helen Barone |
| Judith Malina | Aunt Dottie |
| Lois Markle | Mother Superior |
| Sandra Daley | Nurse Fiona Macken |
| Ivan Martin | Kenny Giacolone |
| Turk Pipkin | Aaron Arkaway |
| Paul Schulze | Father Phil Intintola |
| Gina Tognoni | Catherine Lipman |
| Alberto Vazquez | Julian |
| James Vincent Romano | Cary Di Bartolo |
| Ash Roeca | Rudy Diaz |
| Marcos Muniz | Ramon |
| John 'Cha Cha' Ciarcia | Albie Cianflone |
| Tracey Silver | Beth Kaplan |
| Paul DePasquale | Dispatcher |
| Fiana Toibin | Nurse |
| Felicia Graham | Devonna |
| Lila Blake Palmer | Marvin's Girlfriend
(as Lila Blake-Palmer) |
| Gary Cowling | Nurse Bruce |
| Jojo Gonzalez | Nurse Gilbert Campos |
| Gustavo Cunha | Armando |
| Sallie Toussaint | Blinged-Out Girlfriend |
| Chazz Menendez | Goon |
| Michael Serratore | Driver |
| Joyce Roach | Grandma |
| Keith Thomas Brown | Keshawn
(as Keith Brown) |
| Hal Holbrook | John Schwinn |
| Dionne Audain | Nurse
(uncredited) |
| Lloyd Booker | Resturant Patron
(uncredited) |
| Dono Cunningham | Doctor
(uncredited) |
| Luis Dalmasy Jr. | Orderly
(uncredited) |
| Jonah Falcon | Dave
(uncredited) |
| Katherine Hoskins Mackey | Surgeon
(uncredited) |
| Andrew Kaempfer | Golf Caddy
(uncredited) |
| Jeremy J. Sullivan | Fruit Basket Deliveryman
(uncredited) |
| Dared Wright | Hospital Worker
(uncredited) |