| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi
(credit only) |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Aida Turturro | Janice Soprano Baccalieri |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Joseph R. Gannascoli | Vito Spatafore |
| Dan Grimaldi | Patsy Parisi |
| Jerry Adler | Hesh Rabkin |
| Ron Leibman | Dr. Lior Plepler |
| Henry O | Monk #1 |
| Sheila Kelley | Lee
(as Sheila Kelly) |
| Ho Chow | Monk #2
(as Ho 'Oyster' Chow) |
| Tony Darrow | Larry Boy Barese |
| Robert Funaro | Eugene Pontecorvo |
| Arthur J. Nascarella | Carlo Gervasi
(as Arthur Nascarella) |
| Allan Wasserman | Perry Benedek |
| Matt Servitto | Agent Dwight Harris |
| Sharon Angela | Rosalie Aprile |
| Maureen Van Zandt | Gabriella Dante |
| Michael Kelly | Agent Ron Goddard |
| Will Janowitz | Finn Detrolio |
| Danny Johnson | Detective DeLeon |
| Ted Koch | Detective Klinger |
| Suzanne DiDonna | Deanne Pontecorvo
(as Suzanne Di Donna) |
| Taleb Adlah | Ahmed |
| Donnie Keshawarz | Muhammed |
| Danielle Di Vecchio | Barbara Giglione |
| Anjali Bhimani | Dr. Budraja |
| Christopher Evan Welch | ER Doctor |
| C.S. Lee | Dr. Ba |
| Lee R. Sellars | Salesman
(as Lee Sellars) |
| Traci Kindell | Nurse Leontine Overall
(as Traci Lynne Kindell) |
| Jason Edwards | Psychologist
(as Jay Edwards) |
| Edward Watts | Bartender |
| Luz Lor | Nurse Aquino |
| Scott Davidson | Bald Guy |
| Barbara Pindle | Nurses Aide |
| Gary Cowling | Nurse Tuthill |
| Austin Jones | Omni Clerk |
| Thomas Russo | Robbie Pontecorvo |
| Grace Van Patten | Ally Pontecorvo |
| Quentin Heggs | African-American Guy |
| Jon Shaver | Tall Man |
| Peter O'Hara | Jock Guy |
| Jason Loftus | Bellhop |
| Jay Russell | Clerk |
| Amy Kean | TV Reporter |
| Emily Vaughan | Conference Center Host |
| Kimberly Laughlin | Domenica Baccalieri |
| Brianna Laughlin | Domenica Baccalieri |
| Tommy Bayiokos | Cafeteria Orderly
(uncredited) |
| Randy Blair | Nurse's Aide
(uncredited) |
| Angela Frye | Hospital Orderly
(uncredited) |
| Russell Gibson | Funeral Director
(uncredited) |
| Wendy Hammers | Fake Carmella
(uncredited) |
| Eli Harris | Camera man
(uncredited) |
| Danny Hayden | Barfly
(uncredited) |
| Morgan Saylor | Young Meadow
(uncredited) |
| Sonny Vellozzi | Country Club Member
(uncredited) |
| Dared Wright | Hospital Worker
(uncredited) |