| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Steven Van Zandt | Silvio Dante |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano
(as Jamie-Lynn DiScala) |
| Aida Turturro | Janice Soprano |
| Steve Schirripa | Bobby 'Bacala' Baccalieri
(as Steven R. Schirripa) |
| Vincent Curatola | Johnny 'Sack' Sacramoni |
| John Ventimiglia | Artie Bucco |
| Kathrine Narducci | Charmaine Bucco
(as Katherine Narducci) |
| Steve Buscemi | Tony Blundetto |
| Jerry Adler | Hesh Rabkin |
| Tim Daly | J.T. Dolan |
| Polly Bergen | Fran Felstein |
| Joseph Siravo | Johnny Boy Soprano |
| Richard Portnow | Harold 'Mel' Melvoin |
| Frank Vincent | Phil Leotardo |
| Laurie Williams | Young Livia Soprano
(as Laurie J. Williams) |
| Danny Petrillo | Teenage Tony Soprano |
| Rae Allen | Aunt Quintina Blundetto |
| Carl Capotorto | Little Paulie Germani |
| Leslie Bega | Valentina La Paz |
| Joseph R. Gannascoli | Vito Spatafore |
| Max Casella | Benny Fazio |
| Arthur J. Nascarella | Carlo Gervasi
(as Arthur Nascarella) |
| Kevin Hagan | Chick Philips |
| Paul Schulze | Father Phil Intintola |
| Angelo Massagli | Bobby Baccalieri Jr. |
| Miryam Coppersmith | Sophia Baccalieri |
| Danielle Di Vecchio | Barbara Giglione |
| Frank Santorelli | Georgie |
| Jeffrey M. Marchetti | Petey |
| Allen Enlow | Dr. Harry Winer |
| Charles Santy | Cesar |
| John Marinacci | Dealer |
| Anthony Spina | Relief Dealer |
| Artie Pasquale | Burt |
| Carolyn C. Buccino | Old Woman |
| Fred Caiaccia | Uncle Zio |
| Chris Caldovino | Billy Leotardo |
| Ralph Lucarelli | Cozzarelli |
| Joanna Bonaro | Hysterical Woman |
| Lucian Buscemi | Boy in restaurant
(uncredited) |
| Mike Caravella | Italian Ice Man
(uncredited) |
| Greg D'Agostino | Wiseguy
(uncredited) |
| Keith Leonard | Bar Patron
(uncredited) |