| James Gandolfini | Tony Soprano |
| Lorraine Bracco | Dr. Jennifer Melfi |
| Edie Falco | Carmela Soprano |
| Michael Imperioli | Christopher Moltisanti |
| Dominic Chianese | Junior Soprano |
| Vincent Pastore | Salvatore 'Big Pussy' Bonpensiero |
| Steven Van Zandt | Silvio Dante |
| Tony Sirico | Paulie 'Walnuts' Gualtieri |
| Robert Iler | A.J. Soprano |
| Jamie-Lynn Sigler | Meadow Soprano |
| Nancy Marchand | Livia Soprano |
| Michael Rispoli | Jackie Aprile |
| Al Sapienza | Mikey Palmice |
| Anthony DeSando | Brendan Filone
(as Anthony Desando) |
| Drea de Matteo | Adriana La Cerva |
| Frank Santorelli | Georgie |
| Johann Carlo | Bonnie DiCaprio |
| Debrah Ellen Waller | Perrilyn |
| Mike Epps | Jerome |
| Yancey Arias | Arnaz |
| Tibor Feldman | U.S. Attorney Braun |
| Harvey Levin | Talk Show Host |
| Steven Randazzo | Vincent Rizzo |
| Kate Anthony | Counter Person |
| Anthony Caso | Martin Scorsese |
| Victor Colicchio | Joe |
| Marcia Haufrecht | Fanny |
| Desiree Kehoe | Nude Dancer |
| Michael Parr | Bouncer |
| Sharif Rashed | Antjuan |
| Charles Santy | Truck Driver |
| David Moritt | Mr. Miller
(as David Schulman) |
| Manny Siverio | 2nd Truck Driver
(as Manny Silverio) |
| J.D. Williams | Special K
(as JD Williams) |