| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| David Zayas | Lt. Angel Batista |
| Aimee Garcia | Jamie Batista |
| Geoff Pierson | Deputy Chief Tom Matthews |
| James Remar | Harry Morgan
(credit only) |
| Charlotte Rampling | Dr. Evelyn Vogel |
| Sean Patrick Flanery | Jacob Elway |
| Aaron McCusker | A.J. Yates |
| Bethany Joy Lenz | Cassie Jollenston |
| Sam Underwood | Zach Hamilton |
| Dora Madison | Niki Walters
(as Dora Madison Burge) |
| John D'Aquino | Ed Hamilton |
| Rolando Molina | Armando |
| Jadon Wells | Harrison Morgan |
| Dana L. Wilson | Det. Angie Miller |
| Alex Lewis | Marty
(as Alexander Lewis) |
| Laura Patalano | Housekeeper |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |