| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Capt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| Colin Hanks | Travis Marshall |
| Yasiin Bey | Brother Sam
(as Mos) |
| Edward James Olmos | Prof. James Gellar |
| Geoff Pierson | Deputy Chief Tom Matthews |
| Aimee Garcia | Jamie Batista |
| Billy Brown | Det. Mike Anderson |
| Brea Grant | Ryan Chambers |
| Evan George Kruntchev | Harrison Morgan |
| Luke Andrew Kruntchev | Harrison Morgan |
| Jamie Silberhartz | Erin Baer |
| Germaine De Leon | Nick |
| David Carey Foster | Doctor |
| Jason Ross-Azikiwe | Preacher
(as Jason Azikiwe) |
| Scott Ward | Pastor |
| Nicole Pettis | Reporter |
| Asanio Lara | Gardener |
| Karen Levine | Erin (Stand In) |
| Sommer Fehmel | Bystander
(uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Julie McKinnon | Nurse
(uncredited) |
| Rubi Myers | Screaming Kid
(uncredited) |