| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| Julia Stiles | Lumen Ann Pierce |
| Jonny Lee Miller | Jordan Chase |
| Peter Weller | Stan Liddy |
| Maria Doyle Kennedy | Sonya |
| Christina Robinson | Astor Bennett |
| Preston Bailey | Cody Bennett |
| Michael Ray Escamilla | Street Vendor |
| Derek Basco | Records Clerk |
| Kathleen Noone | Maura Bennett |
| Steve Eastin | Bill Bennett |
| Brian Oblak | Uni |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Brooklynne James | Barrel Girl Victim #11
(uncredited) |
| Evan George Kruntchev | Harrison Morgan
(uncredited) |
| Luke Andrew Kruntchev | Harrison Morgan
(uncredited) |
| Costa Nicolas | Death Man Joe
(uncredited) |
| Jena Sims | Masuka's Date
(uncredited) |
| Chris Vance | Cole Harmon
(uncredited) |