| Michael C. Hall | Dexter Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| Julia Stiles | Lumen Ann Pierce |
| Peter Weller | Stan Liddy |
| Maria Doyle Kennedy | Sonya |
| April Hernandez Castillo | Off. Cira Manzon |
| Raphael Sbarge | Jim McCourt |
| Katherine Moennig | Michael Angelo |
| Chris Payne Gilbert | Robert Brunner |
| Saxon Trainor | Hotel Clerk |
| Tasia Sherel | Francis |
| Erica Shaffer | Teddy's Mom |
| Henree Alyse | Second Mom
(as Henreé Alyse) |
| Annie Tedesco | Playgroup Director |
| Eddy Martin | Jandro Mendoza |
| Sophia Santi | Elena Mendoza |
| Christopher Weir | Bearded Toughguy |
| Deborah Carson | Reporter |
| Stephanie Garrett | Female TSA Attendant |
| Daniel Kash | Male TSA Attendent |
| Erick Chavarria | Taxi Driver
(as Erick Chavarría) |
| Ana Tuazon Parsons | Waitress
(as Ana Parsons) |
| Adrian Bustamante | Mario
(uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Evan George Kruntchev | Harrison Morgan
(uncredited) |
| Luke Andrew Kruntchev | Harrison Morgan
(uncredited) |
| Ciel Turich | Print Photographer
(uncredited) |
| Evan E. Yu | Sex Offender
(uncredited) |