| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| John Lithgow | Arthur Mitchell |
| Geoff Pierson | Deputy Chief Tom Matthews |
| Courtney Ford | Christine Hill |
| Rick Peters | Elliot |
| Jake Short | Scott Smith |
| Chad Todhunter | Kyle Butler #1 |
| Ian Patrick Williams | Stan Beaudry |
| Frederick Koehler | Neighbor
(as Fred Koehler) |
| Roger Ranney | Nick Smith |
| Eric George | Detective
(as Eric K. George) |
| Keith Gordon | Kyle Butler #2 |
| Leyna Nguyen | News Anchor |
| Fred Ochs | Judge Belford |
| Heather Olt | Uni |
| Jennifer DeFilippo | Desk Officer |
| J.R. Cacia | Off. Gordon |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Sandra Medina | Police Officer
(uncredited) |
| Shanelle Renet | Reporter
(uncredited) |