| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Morgan |
| Jennifer Carpenter | Debra Morgan |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Sgt. Angel Batista |
| James Remar | Harry Morgan |
| John Lithgow | Arthur Mitchell |
| Geoff Pierson | Deputy Chief Tom Matthews |
| David Ramsey | Anton Briggs |
| Courtney Ford | Christine Hill |
| Julia Campbell | Sally Mitchell |
| Christina Robinson | Astor Bennett |
| Preston Bailey | Cody Bennett |
| Brando Eaton | Jonah Mitchell |
| Vanessa Marano | Rebecca Mitchell |
| Alicia Lagano | Nikki Wald |
| Christopher Darga | Security Guard |
| Olivia Burnette | Pam |
| Jeff Leaf | Clerk |
| Asante Jones | Off. Reece |
| Giovanni Lopes | Off. Nunez |
| Ryan Christiansen | Off. Hanson |
| Leyna Nguyen | News Anchor |
| Keith Carradine | Frank Lundy
(archive footage) (uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Patrick Labyorteaux | Cook at Sandwich Shop
(uncredited) |