| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan
(credit only) |
| Jimmy Smits | ADA Miguel Prado |
| Desmond Harrington | Det. Joseph 'Joey' Quinn |
| David Ramsey | Anton Briggs |
| Liza Lapira | Det. Yuki Amado |
| Mike Erwin | Freebo |
| Christina Robinson | Astor Bennett |
| Jason Manuel Olazabal | Ramon Prado |
| Marc John Jefferies | Wendell Owens |
| Preston Bailey | Cody Bennett |
| Jelly Howie | Teegan Campbell |
| Joel Weiss | Cal Rooney |
| Paul Lieber | Bartender |
| Nick Hermz | Oscar Prado |
| Anthony Tyler Quinn | Dentist |
| Mary Alyce Kania | Karen |
| Yolanda Snowball | Teacher |
| Mario Z. | Elderly Man |
| Bryce Robinson | Kid #1 |
| Kaleigh Kennedy | Kid #2 |
| Vincent King | Kid #3 |
| Darnell J. Cates | Lookout Kid on Bike
(uncredited) |
| Doby Daenger | Taqueria Patron
(uncredited) |
| Alexa Gardner | Taco Stand Customer
(uncredited) |
| Andy Scott Harris | Classroom Kid
(uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Terricka Rogers | Club Goer
(uncredited) |
| Pablo Soriano | Det. Robert Ramos
(uncredited) |
| Michael A. Templeton | District Attorney
(uncredited) |