| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan |
| Geoff Pierson | Capt. Tom Matthews |
| Jonathan Banks | FBI Deputy Director Max Adams |
| Jaime Murray | Lila Tournay |
| Keith Carradine | Special Agent Frank Lundy |
| Christina Robinson | Astor Bennett |
| Preston Bailey | Cody Bennett |
| Eli Goodman | Det. Weiss |
| Mary Alyce Kania | Karen |
| Stephanie Y. Wang | Lexi |
| Darryl Sivad | Minister |
| Troy Metcalf | Cabbie |
| Manny Suárez | Mayor
(as Manny Suarez) |
| Gary Kraus | Sheriff |
| L.T. Tolliver | Uniform Cop
(as LT Tolliver) |
| Maxwell Huckabee | Little Dexter |
| Doby Daenger | Radio Reporter
(uncredited) |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Chris Krauser | Cop
(uncredited) |