| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan
(credit only) |
| Geoff Pierson | Capt. Tom Matthews |
| Peter Macon | Leonis
(credit only) |
| Jonathan Banks | FBI Deputy Director Max Adams |
| Tony Colitti | Dr. Hill |
| Jaime Murray | Lila Tournay |
| Keith Carradine | Special Agent Frank Lundy |
| Christina Robinson | Astor Bennett |
| Preston Bailey | Cody Bennett |
| Cedric Duplechain | Peters |
| Alistair Tober | Borelli |
| Mary Ostrow | Marlene |
| Wilmer Calderon | Teo |
| Gilbert Saldivar | Esteban |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Maria Zambrana | Newsroom Atmosphere
(uncredited) |