| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| C.S. Lee | Vince Masuka |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan
(credit only) |
| Tony Amendola | Santos Jimenez |
| Bruce Weitz | Lenny Asher |
| Jaime Murray | Lila Tournay |
| Keith Carradine | Special Agent Frank Lundy |
| Christina Robinson | Astor Bennett |
| Preston Bailey | Cody Bennett |
| Pablo Soriano | Det. Robert Ramos |
| Matt Borlenghi | Headhunter |
| Ryan Smith | Police Officer
(as Ryan K. Smith) |
| Don Abernathy | FBI Agent
(uncredited) |
| Chris Krauser | Special Agent Eddie Velasco
(uncredited) |
| Wendy Wells-Gunkel | Hotel Z Patron
(uncredited) |