| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan
(credit only) |
| Geoff Pierson | Capt. Tom Matthews |
| C.S. Lee | Vince Masuka |
| Mark Pellegrino | Paul Bennett |
| Christian Camargo | Rudy Cooper |
| Malcolm-Jamal Warner | Rita's Lawyer |
| Martinez Evelina | Monique
(as Tomiko Martinez) |
| Ruth Zalduondo | Social Worker |
| Christina Robinson | Astor Bennett |
| Daniel Goldman | Cody Bennett |
| Maxwell Huckabee | Three-Year-Old Dexter |
| Roxanne Beckford | Reporter Candice DeSallee |
| Wiley M. Pickett | Sheriff
(as Wiley Pickett) |
| Symba | Sexy Woman
(as Symba Smith) |
| Christine Barger | Pierced Chick |
| Sage Kirkpatrick | Woman
(as Katherine Kirkpatrick) |
| Jennifer Shon | Young Clerk |
| Teddy Lane Jr. | Jerry |
| Romeo Brown | Andy |
| Robert Della Cerra | Evidence Room Cop |
| Del Hunter-White | Court Supervisor |
| Bruce Holman | Det. Michael Soderquist
(uncredited) |
| Marc Linsalata | Hotel Manager
(uncredited) |