| Michael C. Hall | Dexter Morgan |
| Julie Benz | Rita Bennett |
| Jennifer Carpenter | Debra Morgan |
| Erik King | Sgt. James Doakes |
| Luna Lauren Velez | Lt. Maria LaGuerta
(as Lauren Velez) |
| David Zayas | Det. Angel Batista |
| James Remar | Harry Morgan |
| C.S. Lee | Vince Masuka |
| Margo Martindale | Camilla |
| Dominic Janes | Young Dexter |
| Christina Robinson | Astor Bennett |
| Daniel Goldman | Cody Bennett |
| Patrick Michael Buckley | Off. Oliver |
| Ethan S. Smith | Jaworski
(as Ethan Smith) |
| Susanne Kreitman Taylor | Det. Sue
(as Susie Taylor) |
| Marc Macaulay | Detective |
| Devon Graye | Teenage Dexter |
| Justin Kane | Off. Simon |
| Neeona Neal | Jane Saunders
(as Neeona Neel) |
| Jeanne Tidwell | Mrs. Donovan |
| Roy Rutland | Desk Sergeant |
| Jim Abele | Mike Donovan
(uncredited) |
| Scott Buckley | Police Detective
(uncredited) |
| Parker Cristan | Crime Scene Investigator
(uncredited) |
| Yvonne Gougelet | Crackhead
(uncredited) |
| Jadin Gould | Young Debra
(uncredited) |
| Steve Lantz | Detective
(uncredited) |
| Karina Michel | Beth
(uncredited) |
| Renier Murillo | Concert Vendor
(uncredited) |
| Brooklyn Murphy | Police Officer
(uncredited) |
| Nicholas Simmons | Murdered Drug Dealer
(uncredited) |
| Frank Tedesco | Miami Dade Police Officer
(uncredited) |