| Kiefer Sutherland | Tom Kirkman |
| Natascha McElhone | Alex Kirkman |
| Adan Canto | Aaron Shore |
| Italia Ricci | Emily Rhodes |
| LaMonica Garrett | Mike Ritter |
| Tanner Buchanan | Leo Kirkman |
| Kal Penn | Seth Wright |
| Maggie Q | Hannah Wells |
| Mckenna Grace | Penny Kirkman |
| Kevin McNally | Harris Cochrane |
| Malik Yoba | Jason Atwood |
| Arjay Smith | Nolan |
| Alex Quijano | Lawrence |
| Richard Bekins | President Robert Richmond |
| Peter Outerbridge | Charlie Langdon |
| Rothaford Gray | Acting Defense Secretary |
| Krista Morin | Acting FBI Director |
| Doug MacLeod | Acting Secretary of State |
| Alicia Nieves | Alicia Nieves |
| Elias Zarou | Ambassador Fayad |
| Matt Smith | Bomb Tech #1 |
| Shawn Ahmed | Bomb Tech #2 |
| Tyler Burton | Caleb |
| Khadijah Roberts-Abdullah | Crying Woman |
| Darlene Cooke | DC Appellate Judge |
| Adrian Griffin | DC Cop |
| Perry Mucci | FBI Tech |
| Jim Hamill | Jim Hamill |
| Robin Cunningham | Major Cameron |
| Dan Duran | News Reporter #1 |
| Nadine Whiteman Roden | News Reporter #2 |
| Rory O'Shea | News Reporter #3 |
| Scott Schaffer | Scott Schaffer |
| Brendan J. Rowland | Secret Service Agent |
| Troy Blundell | Security Guard |
| Sharla McBride | Sharla McBride |
| JaNae Armogan | Speechwriter #1 |
| Kelly Penner | Speechwriter #2 |
| Scott Faulconbridge | Terrified Man |
| Uhraney Adrian | FBI Agent |
| Darrell Duane | Stuffed Seal |
| Darrell Hicks | Secret Service |
| Shane Clinton Jarvis | Secret Service Agent #2 |
| Noam Jenkins | FBI Agent |
| Michael Kinney | Acting Treasury Secretary |
| Julia Knope | Underage Club Goer |
| Dan MacKay | Air Force Major |
| Ali Manek | Waiter 1 |
| Srinivasan Manivannan | IAC Protestors |
| Vincent Marciano | White House Producer |
| Dave Reachill | White House Staff |
| Michael Murray Scratch | Senator Scott Wheeler |
| Jasmine Sean | Wife |
| Catherine Tait | Acting Health and HR Officer |