| Timothy Olyphant | Seth Bullock |
| Ian McShane | Al Swearengen |
| Molly Parker | Alma Garret |
| Jim Beaver | Whitney Ellsworth |
| W. Earl Brown | Dan Dority |
| Dayton Callie | Charlie Utter |
| Kim Dickens | Joanie Stubbs |
| Brad Dourif | Doc Cochran |
| Anna Gunn | Martha Bullock |
| John Hawkes | Sol Star |
| Jeffrey Jones | A.W. Merrick |
| Paula Malcomson | Trixie |
| Leon Rippy | Tom Nuttall |
| William Sanderson | E.B. Farnum |
| Robin Weigert | Calamity Jane |
| Sean Bridgers | Johnny Burns |
| Titus Welliver | Silas Adams |
| Brent Sexton | Harry Manning |
| Bree Seanna Wall | Sofia Metz |
| Powers Boothe | Cy Tolliver |
| Gerald McRaney | George Hearst |
| Pruitt Taylor Vince | Mose Manuel |
| Geri Jewell | Jewel |
| Larry Cedar | Leon |
| Peter Jason | Con Stapleton |
| Michael Harney | Steve |
| Paul Blackthorne | Hearst's man needling Cornishmen |
| Dan Hildebrand | Shaughnessy |
| Seth Peterson | |
| Chase Ellison | Richie |
| Ralph Richeson | Richardson |
| Allan Graf | Captain Turner |
| Parisse Boothe | Tess |
| Meghan Glennon | Lila |
| Kevin P. Kearns | Pasco
(as Kevin Kearns) |
| Dan Conroy | Cornishman |
| David LeBell | |
| Jackson Bridgers | Schoolboy |
| Anna Catharine Brown | Schoolgirl
(as Anna Brown) |
| Sarah Foster | |
| Trevor Knoop | |
| Shelby Rose Storace | |
| Brooke Veluzat | Schoolgirl |
| Elijah Veluzat | |
| George Adams | Prospector
(uncredited) |
| Iris Braydon | Bella Whore
(uncredited) |
| Rex Brown | Man Drinking at Bar #2
(uncredited) |
| Jerry Cantrell | Man Drinking at Bar #1
(uncredited) |
| Al Collado | Store Proprietor
(uncredited) |
| Tim DeZarn | Townsman
(uncredited) |
| Joe Forbes | Townsman
(uncredited) |
| Zvonimir Hace | Prospector
(uncredited) |
| Ashleigh Kizer | Dolly
(uncredited) |
| Michael Lampe | Prospector
(uncredited) |
| Sarah B. Lund | Sara
(uncredited) |