| Timothy Olyphant | Seth Bullock |
| Ian McShane | Al Swearengen |
| Molly Parker | Alma Garret |
| Jim Beaver | Whitney Ellsworth
(credit only) |
| Brad Dourif | Doc Cochran |
| John Hawkes | Sol Star |
| Paula Malcomson | Trixie |
| Leon Rippy | Tom Nuttall |
| William Sanderson | E.B. Farnum |
| Robin Weigert | Calamity Jane |
| W. Earl Brown | Dan Dority |
| Dayton Callie | Charlie Utter |
| Powers Boothe | Cy Tolliver |
| Garret Dillahunt | Jack McCall |
| Ray McKinnon | Reverend H.W. Smith
(as Raymond McKinnon) |
| Sean Bridgers | Johnny Burns |
| Kim Dickens | Joanie Stubbs |
| Kristen Bell | Flora Anderson |
| Ricky Jay | Eddie Sawyer |
| Greg Cipes | Miles Anderson |
| Geri Jewell | Jewel |
| Peter Jason | Con Stapleton |
| Zach Grenier | Andy Cramed |
| Nicolas Surovy | Captain Massie |
| Clay Wilcox | Loudmouth Drunk in the Gem Saloon |
| Bree Seanna Wall | Sofia Metz |
| Everette Wallin | Joey |
| Richard Wharton | Cowboy Outside Bunkhouse |
| Jim Cody Williams | Terrence |
| Al Collado | Store Proprietor
(uncredited) |
| Jeff Feuerhaken | Prospector
(uncredited) |
| Michael Keyes | Gun Store Owner
(uncredited) |