| Anya Taylor-Joy | Beth Harmon |
| Marielle Heller | Alma Wheatley
(archive footage) |
| Thomas Brodie-Sangster | Benny Watts |
| Harry Melling | Harry Beltik |
| Chloe Pirrie | Alice Harmon |
| Marcin Dorocinski | Vasily Borgov |
| Janina Elkin | Borgov's Wife |
| Maximilian Frisch | Young Borgov
(as Maximillian Fritsche) |
| Dolores Carbonari | Margaret |
| Richard Waugh | Mr. Bradley |
| Alexander Albrecht | Manfredi |
| Jeremy Mockridge | Friedman |
| Frederik Funke | Third Opponent |
| Alec Dahmer | Teenage Reporter |
| Ben Gageik | Weiss |
| Murat Dikenci | Poker Player
(uncredited) |
| David Masterson | Newsreel Reporter
(voice) (uncredited) |
| Martin Müller | Reporter
(uncredited) |
| Kyndra Sanchez | Methuen Orphanage Girl
(voice) (uncredited) |
| Sarah Schubert | Woman #2
(uncredited) |