| Joe Mantegna | David Rossi |
| Shemar Moore | Derek Morgan |
| Matthew Gray Gubler | Dr. Spencer Reid |
| A.J. Cook | Jennifer Jareau |
| Kirsten Vangsness | Penelope Garcia |
| Jennifer Love Hewitt | Kate Callahan |
| Thomas Gibson | Aaron Hotchner |
| Rochelle Aytes | Savannah Hayes |
| James Austin Kerr | Connor Holt |
| Ian Nelson | William Pratt |
| Shelley Robertson | Detective Dawn Rosenburg |
| Paul McKinney | Charles Lorne |
| Ana Walczak | Tara Harris |
| Jay Renshaw | Riley Summers |
| Seth Ginsberg | Daniel Osbourne |
| Kathleen Ammermuller | Nurse Velma Bradford |
| Nazanin Nour | Dr. Joyce Giles |
| Keiko Elizabeth | Reporter Sara Denslyn |
| Andy Manning | Lee Hall
(as Andrew Manning) |
| Tara Christopher | Priscilla Abel |
| Jason Sino | Kyle Bridge |
| Chris Prascus | Alexander Chase |
| Alyssa Gabrielle Rodriguez | Kimmy |
| Tristan James Bower | Reporter
(uncredited) |
| Dennis D'Antin | Reporter
(uncredited) |
| Gev Kalian | Austin Bateman
(uncredited) |
| Rebecca Kessler | Pedestrian
(uncredited) |