| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers
(credit only) |
| Jon Huertas | Javier Esposito |
| Seamus Dever | Kevin Ryan |
| Tamala Jones | Lanie Parish |
| Molly C. Quinn | Alexis Castle |
| Penny Johnson Jerald | Captain Victoria Gates
(credit only) |
| Paula Newsome | Debbie Parker |
| Josh Dean | Jim Kogut |
| Inbar Lavi | Farrah Darwaza |
| Maya Stojan | Tory Ellis |
| Nick Greene | Aiman Haddad |
| Kincaid Walker | Marilyn Singer |
| Lisa Kaminir | Captain Edmunds |
| Roy Werner | Victor Dietrich |
| Adrian Bustamante | Chris |
| Christian Gehring | Conrad Hayward |
| Ben D. Goldberg | Aaron Rich |
| Chris Erric Maddox | Kris |
| Reamy Hall | Reading Passenger |
| John Mawson | 1st Class Passenger |
| Brien Perry | Air Marshal Kyle Ford |
| Tanda Kerín | Flight Attendant
(uncredited) |