| Nathan Fillion | Richard Castle |
| Stana Katic | Kate Beckett |
| Susan Sullivan | Martha Rodgers |
| Ruben Santiago-Hudson | Captain Roy Montgomery |
| Molly C. Quinn | Alexis Castle
(as Molly Quinn) |
| Jon Huertas | Javier Esposito |
| Tamala Jones | Lanie Parish
(credit only) |
| Seamus Dever | Kevin Ryan |
| Thomas Calabro | Scott Donner |
| Stephen Macht | Bill Wellington |
| Juliana Dever | Jenny Duffy-O'Malley |
| Randall Batinkoff | Brad Williams |
| Tymberlee Hill | Julie Taylor |
| David Parker | Duke Jones |
| Laura Prepon | Natalie Rhodes |
| Kelly Thiebaud | Chloe Graves |
| John L. Curtis | Desk Clerk |
| Jon Briddell | Richard Weiss |
| René Ashton | Amelia Weiss |
| Melody Thomas Scott | Tonya Wellington |
| Lenny Citrano | Lead Lawyer |
| James Andrew Walsh | Desperate Man |
| Juan Alfonso | Delivery Man |
| Schae Harrison | Uniform Police Officer Velazquez |
| Andrea Harrison | Jolene Anderson
(uncredited) |
| Adam O'Byrne | Mr. Rubens
(uncredited) |
| Sahlima | Vicky Rubens
(uncredited) |
| Monica Staggs | Stacey Collins
(uncredited) |