| Reese Witherspoon | Madeline Martha Mackenzie |
| Nicole Kidman | Celeste Wright |
| Shailene Woodley | Jane Chapman |
| Alexander Skarsgård | Perry Wright |
| Adam Scott | Ed Mackenzie |
| Zoë Kravitz | Bonnie Carlson
(as Zoe Kravitz) |
| James Tupper | Nathan Carlson |
| Jeffrey Nordling | Gordon Klein |
| Laura Dern | Renata Klein |
| Iain Armitage | Ziggy Chapman |
| Sarah Baker | Thea Cunningham |
| Sarah Burns | Gabrielle |
| P.J. Byrne | Principal Warren Nippal |
| Santiago Cabrera | Joseph Bachman |
| Darby Camp | Chloe Mackenzie |
| Gia Carides | Melissa |
| Hong Chau | Jackie |
| Kelen Coleman | Harper Stimson |
| Joseph Cross | Tom |
| Merrin Dungey | Detective Adrienne Quinlan |
| Ivy George | Amabella Klein |
| Molly Hagan | Dr. Moriarty |
| Virginia Kull | Emily Barnes |
| Kathryn Newton | Abigail Carlson |
| Sarah Sokolovic | Tori Bachman |
| Robin Weigert | Dr. Amanda Reisman |
| Larry Bates | Stu |
| Kathreen Khavari | Samantha |
| David Monahan | Bernard |
| Joel Spence | Matt |
| Larry Sullivan | Oren Berg |
| Nelly Buchet | Juliette |
| Lacy Camp | Secretary |
| Chloe Coleman | Skye Carlson |
| Parker Croft | Brent |
| Cameron Crovetti | Josh Wright |
| Nicholas Crovetti | Max Wright |
| Lauren Glazier | Dr. Megan Shapiro |
| Stephen Graybill | Saxon Baker |
| Stacie Greenwell | Lydia |
| Anil Kumar | Dr. Scott Winslow |
| Kimmy Shields | Kelly |
| Angela Ai | Puppeteer |
| Benai Boyd | Puppeteer |
| Danielle Judovits | Puppeteer |
| Chris Kauffmann | Puppeteer
(as Chris M. Kauffmann) |
| Libby Letlow | Puppeteer |
| Ryan O'Connor | Puppeteer |
| Mark Whitten | Puppeteer |
| Anthony Zediker | Accompanist |
| Richard Israel | Theatrical Coordinator |
| Carrie I. Dodd | Traveler at Airport
(uncredited) |