| Reese Witherspoon | Madeline Martha Mackenzie |
| Nicole Kidman | Celeste Wright |
| Shailene Woodley | Jane Chapman |
| Alexander Skarsgård | Perry Wright |
| Adam Scott | Ed Mackenzie |
| Zoë Kravitz | Bonnie Carlson
(as Zoe Kravitz) |
| James Tupper | Nathan Carlson |
| Jeffrey Nordling | Gordon Klein |
| Laura Dern | Renata Klein |
| Iain Armitage | Ziggy Chapman |
| Sarah Baker | Thea Cunningham |
| Sarah Burns | Gabrielle |
| P.J. Byrne | Principal Warren Nippal |
| Santiago Cabrera | Joseph Bachman |
| Darby Camp | Chloe Mackenzie |
| Hong Chau | Jackie |
| Kelen Coleman | Harper Stimson |
| Joseph Cross | Tom |
| Merrin Dungey | Detective Adrienne Quinlan |
| Ivy George | Amabella Klein |
| Virginia Kull | Emily Barnes |
| Kathryn Newton | Abigail Carlson |
| Larry Bates | Stu |
| Kathreen Khavari | Samantha |
| David Monahan | Bernard |
| Joel Spence | Matt |
| Larry Sullivan | Oren Berg |
| Nelly Buchet | Juliette |
| Chloe Coleman | Skye Carlson |
| Parker Croft | Brent |
| Cameron Crovetti | Josh Wright |
| Nicholas Crovetti | Max Wright |
| Kate Rene Gleason | Stacey |
| Keisuke Hoashi | Dr. Leo Chang |
| Kimmy Shields | Kelly |
| Tim True | Detective Walt Gibson |
| Carson Ferry | Student
(uncredited) |
| McKenna Ferry | Student
(uncredited) |
| Sean Leo | Student
(uncredited) |