| David Duchovny | Fox Mulder |
| Gillian Anderson | Dana Scully |
| Mitch Pileggi | Walter Skinner |
| Darin Morgan | Eddie Van Blundht |
| Christine Cavanaugh | Amanda Nelligan |
| Lee de Broux | Eddie Van Blundht Sr. |
| Robert Rozen | Dr. Alton Pugh |
| Paul McGillion | Angry Husband |
| Jennifer Sterling | Angry Wife |
| David Cameron | Deputy |
| Forbes Angus | Security Guard |
| Peter Kelamis | Second Husband |
| P. Lynn Johnson | Health Department Doctor |
| Carrie Cain-Sparks | Duty Nurse
(as Carrie Cain Sparks) |
| Melanie Angel | Nurse
(uncredited) |
| Constance Barnes | O.R. Nurse
(uncredited) |
| Tom Braidwood | Melvin Frohike
(voice) (uncredited) |
| Dean Haglund | Richard 'Ringo' Langly
(voice) (uncredited) |
| Peter Hall | Sheriff
(uncredited) |
| Peter Stenning | Father at hospital
(uncredited) |
| Moneca Stori | Nurse #2
(uncredited) |